Meropenem by injection national library of medicine. Approximately 70% 50% to 75% of a meropenem dose administered intravenously is recovered unchanged in the urine over 12 hours 1. However, it is your obligation to verify such information before using the products purchased from mcguff. The dry powder should be stored at controlled room temperature 2025. Merrem meropenem is only available as an injectable, so its usually only given for serious infections. An investigation of the stability of meropenem in elastomeric infusion. The iv ld 50 of meropenem in rodents is greater than 2000 mgkg. Meronem iv 500mg summary of product characteristics. Administer by iv infusion over about 15 to 30 minutes. Meropenem fda prescribing information, side effects and uses. Meropenem also treats pneumonia and inflammation of the. The usual dose is 500 mg to 1 g by intravenous infusion every 8 hours, depending on.
Meropenem for injection is indicated as a single agent therapy for the treatment of bacterial meningitis caused by streptococcus pneumoniae, haemophilus influenzae, and neisseria meningitidis. Pharmaceutical dosages from meropenem infusion vials mg were prepared in a fume hood using an aseptic, nontouch technique. Meropenem in the treatment of complicated skin and soft tissue. Dailymed meropenem meropenem injection, powder, for. The iv ld50 of meropenem in rodents is greater than 2000 mgkg. Meronem iv 500mg powder for solution for injection or infusion summary of product characteristics smpc by. Meronem iv 500mg summary of product characteristics smpc.
Meropenem injection, meropenem injection manufacturers. Standard aseptic techniques should be used for solution preparation and administration. Meropenem prices, coupons and patient assistance programs. Cosmetic act fdca for merrem meropenem for injection iv. This medicine will not work for colds, flu, or other virus infections this medicine is to be given only by or under the direct supervision of your doctor. Some of these include meningitis, intraabdominal infection, pneumonia, sepsis, and anthrax.
Prepare your injection only when you are ready to give it. Single dose minibags can be infused over 1530 minutes. Learn about the prescription drug meropenem merrem used to treat a variety of bacterial infections. Inhaled methods deliver medication directly to the airway, which is useful for respiratory problems. Get meropenem injection at best price with product specifications. The length of treatment depends on your general health, the type of infection you have, and how well you respond to the medication. All of the above materials were used without further purification.
Skin and soft tissue infections sstis are very frequently encountered in clinical. Meropenem merrem, meronem is a broadspectrum antibacterial agent of the carbapenem family, indicated as empirical therapy prior to the identification of causative organisms, or for disease caused by single or multiple susceptible bacteria in both adults and. Merrem meropenem is an antibiotic thats usually only given in the hospital for serious infections. Administer as iv infusion over about 15 to 30 minutes or as an iv bolus injection over about 3 to 5 minutes. When constituted as instructed see dosage and administration. Meropenem is usually given by intravenous infusion over approximately 15 to 30 minutes see sections 6. Meronem iv 500mg powder for solution for injection or infusion emc.
The medicinal product is supplied in pack sizes of 1 or 10 vialsbottles. Infectious diseases merck manuals professional edition. Meropenem 500 mg injection uses, dosage, side effects. There is no accumulation of repeated doses of meropenem 500 mg every 8 hours, or 1 gram every 6 hours in patients with normal renal function. Meropenem is a member of the carbapenems drug class and is commonly used for intraabdominal infection, meningitis, nosocomial pneumonia, and others. It should be used with caution in patients with central nervous system disorders.
Dailymed meropenem injection, powder, for solution. Meropenem injection comes as a powder to be mixed with liquid and injected intravenously into a vein. Meropenem, sold under the brandname merrem among others, is a broadspectrum antibiotic used to treat a variety of bacterial infections. Medication errors in intravenous drug preparation and. Compare prices, print coupons and get savings tips for meropenem generic merrem and other skin infection, bacterial infection, meningitis, and gastrointestinal infection drugs at cvs, walgreens, and other pharmacies.
Meropenem injection is a prescription medicine that is used to treat certain infections including complicated skin and soft tissue infection, complicated stomach cavity infection, infection during or following childbirth, urinary tract infection, and lower respiratory tract infection in patients with damaged lungs and digestive system. Generic brand, astrazeneca, intravenous iv meropenem was reconstituted with 20 ml water for injection and further diluted with 50 ml of 0. Meropenem 1g powder for solution for injectioninfusion summary of product characteristics. Meropenem injection is used to treat infections caused by bacteria.
Meropenem is usually given by intravenous infusion over approximately 15 to 30 minutes see section 6. Meropenem definition of meropenem by medical dictionary. Trissel, this tool provides clinicians with access to the information they. Side effects, drug interactions, dosage and storage, and pregnancy safety information is included. Using a pari lc plus nebulizer with meropenem many medications are available as inhaled treatments. It can be given at home, but youll have to be taught how to inject it correctly. Meropenem iv 1grambag sd 50ml 24 bagscase hazardous. Intravenous injection introduced directly into a vein or a freely flowing iv line. Meropenem undergoes both filtration and tubular secretion. The solutions should be inspected visually for particles and discolouration prior. Patient was educated on how to take meropenem intravenous as follows. This medication is good for only 5 days after mixing when stored in the refrigerator and protected from light.
Merrem iv meropenem dosing, indications, interactions. Meropenem 500 mg powder for solution for injection or infusion. Switching to iv push, using solutions other than saline, using large volume solutions, or using syringe infusion pumps, may change the stability and compatibility characteristics of the medication to be. Merrem iv meropenem for injection, for intravenous use. Merrem meropenem dose, indications, adverse effects. Critical care intravenous drug administration guide. Tdmmonograph meropenem october 2015, concept version page 2 of 5 caused by pseudomonas aeruginosa. Withdraw all of the withdrawable contents, using a suitable hypodermic needle and syringe, and transfer to a 100ml volumetric flask. Meropenem and its metabolite are readily dialyzable and effectively removed by hemodialysis. Meropenem for injection, usp is a sterile, pyrogenfree, synthetic, carbapenem antibacterial for intravenous administration. Solutions prepared for infusion meropenem concentrations ranging from 1 mgml to 20 mgml re.
Merrem iv meropenem is an antibiotic used to treat certain types of bacterial infections. Monographs for commonly administered intravenous medications in home and community care 2 p a g e meropenem administration2,4,5 can be dispensed as single doses and administered by gravity or pole pump with each nursing visit. A regimen of 500mg iv q6h is able to achieve a similar probability of target attainment with. However, meropenem and doripenem are less active against e. Program and abstracts of the 18th int congr chemother, stockholm 27.
Five of the 6 cases of skin and soft tissue infections were cured or improved with meropenem therapy. Meropenem kabi 500 mg powder for solution for injection or infusion 20 ml glass vials and 100 ml colourless glass bottles, closed with bromobutilic rubber stopper and sealed with aluminium caps. Meropenem novaplus, merrem iv, premierpro rx meropenem there may be other brand names for this medicine. Adenosine rapid iv bolus given by a doctor or under direct supervision 2 seconds can be diluted with ns compatibility with other. How to take meropenem intravenous home health patient. Merrem is used in the treatment of infections of the abdomen, such as appendicitis and peritonitis, bacterial meningitis infection of the lining of the brain, and skin infections. This prior approval supplemental new drug application provides for labeling changes to dosage and administration section, use in adult patients with renal impairment 2. This is a demonstration of how to prepare and administer meropenem using an aseptic nontouch technique antt. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and. Know meropenem 500 mg injection uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions.
Most enterococcus faecalis and many pseudomonas aeruginosa strains, including those resistant to broadspectrum penicillins and cephalosporins, are susceptible to imipenem, meropenem, and doripenem but are resistant to ertapenem. A nebulizer delivery system consists of a nebulizer small plastic medication cup with a lid that drops into the cup and twists and a. Meropenem has not been fdaapproved for administration as a continuous intravenous infusion. You should not receive it if you had an allergic reaction to meropenem or other antibiotics, including penicillins or. List item meronem article 30 referral annex i, ii, iii european.
Meropenem reconstitution instructions 500 mg vial your pet was prescribed meropenem, a liquid intravenous antibiotic for infections. Meropenem 1g powder for solution for injectioninfusion. Meropenem is usually given by intravenous infusion over approximately 15 to 30 minutes alternatively, doses. Continuous an infusion running over more than 1 hour. Meropenem side effects, dosage, interactions drugs. Meropenem 500 mg powder for solution for injection or infusion emc. Find patient medical information for meropenem intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. By continuing to browse this site you are agreeing to our use of cookies. Helps to improve outcomes by verifying iv drug compatibility verifies drug compatibility and stability trissels iv chek api is an electronic tool that verifies the compatibility and stability of parenteral medications. Find out what health conditions may be a health risk when taken with meropenem intravenous. Following intravenous administration, meropenem auc, clr, and total. Intermittent an infusion from a burette or minibag running over approximately 1560 minutes.
Traditional intermittent infusion method over 30 minutes. Available online through esupply using arup connect or contact arup client services at 800 5222787. Merrem iv is supplied in 20 ml and 30 ml injection vials containing sufficient meropenem to deliver 500 mg or 1 gram for intravenous administration, respectively. Meropenem is a recently developed carbapenem antibiotic, similar to imipenem, with a wide spectrum of activity against grampositive and gramnegative bacteria. Based upon the trusted trissels 2 clinical pharmaceutics database by lawrence a. At the end of a 30 minute intravenous infusion of a single dose of meropenem for injection iv in healthy. We would like to show you a description here but the site wont allow us. Medication errors in intravenous drug preparation and administration med j malaysia vol 68 no 1 february 20. Make sure the medication is clear and free of any suspended particles, before use. Mcguff work very hard to provide you accurate and timely information on our website. The king guide to parenteral admixtures is designed to help practitioners decide which alternative administration strategy is best.
Meropenem 1 g powder for solution for injection or infusion. Webmd provides common contraindications for meropenem intravenous. Find patient medical information for meropenem in 0. Do not mix other injectable medications in the same iv bag or tubing with meropenem. Meropenem 500 mg injection is a broad spectrum antibiotic used to treat a variety of conditions caused by bacteria such as infections of stomach, brain, and lungs.
Reconstitute a 1 g vial according to manufacturer recommendations. Also, discard the vial, if contents are cloudy or discolored or if the. Medication errors in intravenous drug preparation and administration med j malaysia vol 68 no 1 february 20 53. Assay preparation 1 where it is represented as being a singledose container constitute a container of meropenem for injection with a volume of water, accurately measured, corresponding to the amount of solvent specified in the labeling. You should not receive it if you had an allergic reaction to meropenem or other antibiotics, including penicillins or cephalosporins. The efficacy of meropenem as monotherapy in the treatment of meningitis caused by penicillin non. In comparison with imipenem, meropenem is relatively stable to hydrolysis by the enzyme dehydropeptidase i dhpi, thus precluding the need for coadministration with an inhibitor of dhpi, such as cilastatin. Discard the vial at the notice of any suspended particles. Look up information on diseases, tests, and procedures. Meropenem is boadly active against resistant enteric gramnegative rods and. It works by killing the bacteria or preventing their growth.
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